Adding a certain compound to certain chemical reactions, such as: 106961-33-5, N,N-Dimethyl-1-(6-methyl-2-(p-tolyl)imidazo[1,2-a]pyridin-3-yl)methanamine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, name: N,N-Dimethyl-1-(6-methyl-2-(p-tolyl)imidazo[1,2-a]pyridin-3-yl)methanamine, blongs to pyridine-derivatives compound. name: N,N-Dimethyl-1-(6-methyl-2-(p-tolyl)imidazo[1,2-a]pyridin-3-yl)methanamine
80 liters of acetone and 8 kg of 2-(4-methyl phenyl)-3-dimethyl amino methyl-6-methyl-[1,2-alpha] imidazo pyridine were taken into a reactor and the mixture was heated to 39 C. The reaction mixture was maintained at 38 to 39 C. for 20 minutes. The reaction mass was then cooled to 26 C. Methyl iodide was pre-cooled to 15 C. and added to the reaction mass under stirring. The reaction mixture was maintained at 27 to 28 C. for 10 hours. Reaction completion was checked using thin layer chromatography. After the reaction was complete, the reaction mass was filtered and the solid was washed with 8 liters of chilled acetone. Into another reactor 60 liters of water and 1.4 kg of sodium cyanide were added. The wet solid obtained above was also added to the reactor and the reaction mass was heated to 84 C. The reaction mixture was maintained at 82 to 84 C. for 12 hours. Reaction completion was checked using high performance liquid chromatography. After the reaction was completed, the reaction mixture was cooled to 55 C. A solution of 12 liters of 48% aqueous sodium hydroxide solution in 40 liters of water was added to the reaction mass. The reaction mixture was heated to 85 C., and maintained for 3 hours. The temperature was slowly raised to 98 C. and maintained under reflux for 13 hours, 30 minutes. Reaction completion was checked using high performance liquid chromatography. After the reaction was complete, the reaction mixture was cooled to 33 C. and filtered through a Celite bed and the bed was washed with 8 liters of water. The filtrate was taken into a fresh reactor and washed with 40 liters of toluene in two equal lots. The pH of the filtrate was adjusted to 5.3 with 14 liters of acetic acid. After completion of the pH adjustment, the filtrate was maintained at 25 C. for 4 hours. The separated solid was filtered and washed with 16 liters of water in two equal lots. The wet solid was dried at 85 C. and a vacuum of 650 mm Hg for 12 hours to yield 5.6 kg of the title compound. (Yield 69.73%) Purity by HPLC: 98.2%.
The synthetic route of 106961-33-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Padi, Pratap Reddy; Bollikonda, Satyanarayana; Jasty, Ananda Mohan; Tamma, Ranga Reddy; Mohanarangam, Saravanan; Yasareni, Sumalatha; Rupakala, Gowri Shanker; Debasish, Ghosh; US2007/27180; (2007); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem