Electric Literature of 868551-30-8 , The common heterocyclic compound, 868551-30-8, name is Methyl 4-methyl-5-nitropicolinate, molecular formula is C8H8N2O4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
A mixture of methyl 4-methyl-5-nitropyridine-2-carboxylate (3.5g, 17.8mmol), dimethylformamide dimethylacetal (DMF-DMA) (3.6ml, 1.5eq) in acetonitrile (35mL) was heated in a microwave at 140C for 20 min. The solvent was removed. The residue (5.1 g) was carried onto the next step without further purification.
The synthetic route of 868551-30-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; PFIZER INC.; WO2005/103003; (2005); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem