A new synthetic route of Electric Literature of 76041-72-0

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,76041-72-0, its application will become more common.

Electric Literature of 76041-72-0 ,Some common heterocyclic compound, 76041-72-0, molecular formula is C6H4F3NS, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Intermediates 4: a) 5-Trifluoromethyl-pyridine-2-sulfonyl chloride (4a); 0.8 g (4.47 mmol) of 5-trifluoromethyl-pyridine-2-thiol is placed at -8C in 16 m L of H2S04. 16.96 mL (35.7 mmol) of a 13% sodium hypochlorite solution is poured gently such that the temperature of the reaction medium does not exceed 5C. This mixture is then stirred for 45 min, taken up by water and then extracted using AcOEt. After drying followed by reduction to dryness of the organic phases, an oil is isolated (yield: 79%) and used as such for the next reactions.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,76041-72-0, its application will become more common.

Reference:
Patent; PIERRE FABRE MEDICAMENT; DUPONT-PASSELAIGUE, Elisabeth; LE ROY, Isabelle; PIGNIER, Christophe; WO2012/69503; (2012); A1;,
Pyridine – Wikipedia,
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