Related Products of 94220-38-9 , The common heterocyclic compound, 94220-38-9, name is 7-Chloro-5-methyl-1H-pyrazolo[4,3-b]-pyridine, molecular formula is C7H6ClN3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
EXAMPLE 9 7-(3-Dimethylaminopropylamino)-5-methyl-1H-pyrazolo[4,3-b]pyridine hydrochloride, monohydrate (E9) STR23 A mixture of 7-chloro-5-methyl-1H-pyrazolo[4,3-b]pyridine (D4) (19.21 g, 0.115 mole) and 3-dimethylaminopropylamine (100 g) in xylene (770 ml) was heated at reflux under nitrogen for 83 h. After allowing to cool to room temperature, volatile material was removed under reduced pressure. The residue, an orange oil, was treated with ether and methanol and then left to stand at 4 C. overnight. The resulting pale yellow crystalline solid was collected, washed with ether/methanol and dried under vacuum to give the title compound (12.5 g, 38%), m.p. 183-186 C. (Found: C,50.29; H,7.53; N,24.44. C12 H19 N5.HCl.H2 O requires: C,50.08; H,7.69; N,24.34%). delta(DMSO-d6) 1.88-2.05 (2H,m); 2.47 (3H,s); 2.53 (6H,s); 2.82-2.95 (2H,m); 3.32-3.47 (2H,m); 6.37 (1H,s); 7.9 (1H, brs); 8.01 (1H, s);
The synthetic route of 94220-38-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Beecham Group p.l.c.; US4670432; (1987); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem