Reference of 154078-83-8, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 154078-83-8, name is Ethyl 2-(3-nitropyridin-2-yl)acetate. This compound has unique chemical properties. The synthetic route is as follows.
To a solution of ethyl 2-(3-nitropyrid-2-yl)acetate (1.05 g, 5 mmol, 1.0 eqin DMF (10 mL) was added DMF-DMA (0.9 g, 7.5 mmol, 1.5 eq). The mixture was stirred at rt overnight. The mixture was poured into water (50 mL), extracted with EA (50 mL x 2). The organic layer was washed with water (50 mL x 2) and brine (50 mL x 2), dried over sodium sulfate, concentrated to afford ethyl 3-(dimethylamino)-2-(3-nitropyrid-2-yl)propenoate (650 mg, 50%) which was used in next step directly. LCMS: (M+H)+: 265.9.
According to the analysis of related databases, 154078-83-8, the application of this compound in the production field has become more and more popular.
Reference:
Patent; CS PHARMASCIENCES, INC.; SONG, Yuntao; BRDIGES, Alexander, James; (524 pag.)WO2017/120429; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem