Synthetic Route of 61494-55-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 61494-55-1, name is 2-(2-Chloropyridin-3-yl)acetic acid, molecular formula is C7H6ClNO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
At -78 C., 19.6 ml of 1.9 mol/L solution of hexamethyldisilazane sodium in THF was added dropwise to 100 ml of THF solution containing 2.00 g of 2-(2-chloropyridin-3-yl)acetic acid, and the mixture was stirred for 10 minutes. Next, 1.50 ml of methyl p-fluorobenzoate was added dropwise. The mixture was then brought from -78 C. to room temperature and was stirred for 1 hour. Saturated aqueous ammonium chloride solution was added thereto, and the mixture was stirred. Thereafter, ethyl acetate was added, and the resultant liquid mixture was separated. The obtained organic layer was washed with saturated brine and was dried over sodium sulfate. The solvent was distilled off under reduced pressure, and the resultant residue was purified by silica gel column chromatography. The title compound was obtained as a colorless amorphous compound weighing 1.45 g. 1H-NMR(CDCl3)delta:8.36(1H,dd,J=4.6,1.9 Hz),8.11-8.07(2H,m),7.62(1H,dd,J=7.4,1.9 Hz),7.27-7.24(1H,m),7.21-7.17(2H,m),4.42(2H,s).
According to the analysis of related databases, 61494-55-1, the application of this compound in the production field has become more and more popular.
Reference:
Patent; MITSUI CHEMICALS AGRO, INC.; UMETANI, Hideki; FUKUMOTO, Takeshi; NAITO, Ryohei; IKISHIMA, Hideaki; KOUNO, Toshiyuki; NISHIDA, Akihiro; YANAGI, Masanori; KITAJIMA, Kazuki; YUTANI, Satoshi; SHIRAKAWA, Tomomi; OHARA, Toshiaki; (170 pag.)US2019/380340; (2019); A1;,
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