Adding a certain compound to certain chemical reactions, such as: 13958-85-5, 3-Fluoro-5-methylpyridin-4-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, COA of Formula: C6H7FN2, blongs to pyridine-derivatives compound. COA of Formula: C6H7FN2
General procedure: Pd2dba3 (8.25 mg, 9.01 pmol), XantPhos (13.0 mg, 22.5 pmol) and Cs2C03 (110 mg, 0.34 mmol) were dissolved in DMF (2.25 mL) in a sealed tube while N2 was bubbling. 1-49 (42.0 mg, 0.25 mmol) and 1-1 (53.5 mg. 0.23 mmol) were added and the reaction mixture was stirred at room temperature for 10 min. Then, the reaction mixture was heated at 110 C for 20 h. The reaction mixture was cooled to room temperature, filtered through Celite and washed with EtOAc. The solvent was removed under reduced pressure and the crude mixture was purified by reverse phase column chromatography (mobile phase: HCOOH (0.l%)/(MeCN:MeOH, 1 :1), gradient from 95:5 to 63:37) to afford compound 91 (42 mg, 50%) as a white solid.
The synthetic route of 13958-85-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; JANSSEN PHARMACEUTICA NV; BARTOLOME-NEBREDA, Jose Manuel; TRABANCO-SUAREZ, Andres, Avelino; LEENAERTS, Joseph, Elisabeth; OEHLRICH, Daniel; BUIJNSTERS, Peter Jacobus Johannes Antonius; MARTINEZ LAMENCA, Carolina; VELTER, Adriana, Ingrid; VAN ROOSBROECK, Yves, Emiel, Maria; (110 pag.)WO2019/243533; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem