Adding a certain compound to certain chemical reactions, such as: 113293-70-2, 2,6-Dichloroisonicotinaldehyde, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 113293-70-2, blongs to pyridine-derivatives compound. Application In Synthesis of 2,6-Dichloroisonicotinaldehyde
To a solution of commercially available 2,6-dichloropyridine-4-carbaldehyde (0.3 g, 1.7 mmol) in CH2CI2 (34 ml.) under N2 at -78 0C is added DAST (0.67 ml_, 5.1 mmol). The reaction is allowed to warm to room temperature, stirred 1 h, and poured into cold water. The separated aqueous layer is extracted with fresh CH2CI2 The combined organic layers are dried (Na2SO4), concentrated, and purified by flash chromatography (10% EtOAc/heptanes) to yield an orange oil: 1H NMR (400 MHz, CDCI3) delta ppm 6.60 (t, J=55.1 Hz, 1 H), 7.40 (s, 2 H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,113293-70-2, its application will become more common.
Reference:
Patent; NOVARTIS AG; WO2009/150230; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem