In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 934279-60-4, name is 2-Chloro-5-(trifluoromethyl)nicotinaldehyde, the common compound, a new synthetic route is introduced below. Recommanded Product: 934279-60-4
To a solution of 2-chloro-5- (trifluoromethyl)nicotinaldehyde (272 mg, 1.30 mmol) in THF (2 ml) was added methylmagnesium bromide (0.865 ml, 2.60 mmol). The reaction was stirred at 20 C for 1hour, then quenched with water (10 mL) and extracted with EtOAc (10 mL x 3). The combined organic layers were washed with brine (30 mL), dried (Na2SO4), filtered. The filtrate was evaporated under reduced pressure to give the title compound, which was used+directly in the next step without purification. MS(ESI) m/z: 226.0 [M+Hj H NMR(400MHz, CDC13): oe = 8.56 (br. s., 1H), 8.23 (s, 1H), 5.31 – 5.22 (m, 1H), 1.54 (d, J 6.4Hz, 3H)
The synthetic route of 934279-60-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; MERCK SHARP & DOHME CORP.; MILLER, Michael; CHOBANIAN, Harry, R.; HE, Shuwen; HAO, Jinsong; PIO, Barbara; GUO, Yan; XIAO, Dong; (213 pag.)WO2018/118670; (2018); A1;,
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