Adding a certain compound to certain chemical reactions, such as: 64951-08-2, Imidazo[1,2-a]pyridine-2-carboxylic acid, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 64951-08-2, blongs to pyridine-derivatives compound. category: pyridine-derivatives
To a solution of carboxylic acid (1.1 g, 7 mmol) in dry DCM (10 mL) at 0C under nitrogen was added B (1.5 mg, 7 mmol), Et3N (2.1 g, 21 mmol), EDCI (4.7 g, 23.8 mmol), HOBt (2.8 g, 21 mmol) and DMAP (150 mg, catalytic). Reaction mixture was stirred at 25C for 2-12 h, monitored by TLC. Mixture was poured into cold water (10 ml) and extracted with DCM (20ml), washed with water and brine, then dried and concentrated. Crude material was purified by column chromatography (silica gel, EtOAc_PE=l :2) to give C (751 mg, 30%) as a yellow solid.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,64951-08-2, its application will become more common.
Reference:
Patent; THE CALIFORNIA INSTITUTE FOR BIOMEDICAL RESEARCH; THE SCRIPPS RESEARCH INSTITUTE; THE GLOBAL ALLIANCE FOR TB DRUG DEVELOPMENT, INC.; CHATTERJEE, Arnab, K.; WANG, Feng; SCHULTZ, Peter, G.; XU, Chunping; AJAYI, Kehinde; WANG, Jianing; HALDER, Rajkumar; KUMAR, Puneet; YANG, Baiyuan; LIU, Renhe; CHENG, Bo; KANEKO, Takushi; WO2014/190199; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem