Related Products of 72716-80-4, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 72716-80-4, name is 5,6-Dimethyl-2-oxo-1,2-dihydropyridine-3-carbonitrile. A new synthetic method of this compound is introduced below.
Step (iii): Synthesis of 2-Chloro-5,6-dimethyl pyridin-3-carbonitrile; Phosphorus oxychloride (15 mL) was added to 2-oxo-l,2-dihydro-5,6-dimethyl pyridine-3-carbonitrile (2.00 g, 13.5 mmol) in a two neck 50 mL round bottom flask, and this mixture was stirred at RT for 1 h, and then refluxed for 12 h. Afterwards, the excess phosphorous oxychloride was distilled off, and the residue was poured into ice cooled water. The aqueous solution was basified with saturated sodium bicarbonate solution, and the precipitate that fo?ned was filtered off to afford the title compound (1.50 g), yield: 66.7%. mrho:110 C1H NMR (DMSCW15, 200 MHz): d 7.94 (s, IH), 2.55 (s, 3H), 2.31 (s, 3H); m/z (CI-MS) 167 (M++l, 100 %) ; IR (Neat, cm”1): 3420, 2231
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,72716-80-4, its application will become more common.
Reference:
Patent; REDDY US THERAPEUTICS, INC.; BARUAH, Anima; DE, Dibyendu; KHANNA, Ish Kumar; PILLARISETTI, Sivaram; MAITRA, Santanu; ALEXANDER, Christopher, W.; SREENU, Jennepalli; DAGER, Indu; WO2006/73973; (2006); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem