Application of 582303-10-4, Adding some certain compound to certain chemical reactions, such as: 582303-10-4, name is (2,6-Dimethylpyridin-3-yl)methanol,molecular formula is C8H11NO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 582303-10-4.
To a mixture of methyl ( 6-hydroxy-4- (trifluoromethyl ) -1- benzothiophen-3-yl ) acetate (60 mg) and THF (dry) (2 mL) were added (2, 6-dimethylpyridin-3-yl)methanol (31.2 mg) , ADDP (62.6 mg) , and tri-n-butylphosphine (0.153 mL) at room temperature. After stirring at room temperature for 16 h, the insoluble material was removed by filtration. The filtrate was concentrated in vacuo. The residue was purified by silica gel column chromatography (EtOAc/hexane) . To the mixture of crude material and THF (1 mL) was added IN NaOH (1 mL) at room temperature, and the mixture was stirred at room temperature for 13 h. The mixture was neutralized with IN HC1 at 0C and extracted with EtOAc. The organic layer was separated, washed successively with water and brine, dried over MgS04 and concentrated in vacuo. The residual solid was crystallized from EtOAc-hexane to give the title compound (71.0 mg) . XH NMR (300 MHz, DMSO-d6) delta 2.43 (3H, s) , 2.51 (3H, d, J = 1.1 Hz), 3.90 (2H, s), 5.24 (2H, s) , 7.10 (1H, d, J = 7.6 Hz), 7.49 (1H, d, J = 2.6 Hz), 7.67-7.75 (2H, m) , 8.09-8.14 (1H, m) , 12.34 (1H, brs) .
According to the analysis of related databases, 582303-10-4, the application of this compound in the production field has become more and more popular.
Reference:
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; TAKAKURA, Nobuyuki; BANNO, Yoshihiro; TERAO, Yoshito; OCHIDA, Atsuko; MORIMOTO, Sachie; KITAMURA, Shuji; TOMATA, Yoshihide; YASUMA, Tsuneo; IKOMA, Minoru; MASUDA, Kei; WO2013/125732; (2013); A1;,
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