Electric Literature of 800401-70-1 ,Some common heterocyclic compound, 800401-70-1, molecular formula is C10H9BrN2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
PdCl2 (PPh3) 2 (0.026g, 0.037mmol) and Cu (I) I (0.007g, 0. 037MMOL) were added sequentially to 5-BROMO-LH-PYRROLO [2,3-c] pyridine-2-carboxylic acid ethyl ester (Preparation 26, 0. 100G, 0.370mmol) under an argon atmosphere. 1,4-Dioxane (7mL, anhydrous) followed by DIISOPROPYLAMINE (0.063mL, 0. 45MMOL) were added and the stirred mixture was purged with argon for 5min. Trimethylsilylacetylene (0.064mL, 0. 45MMOL) was added dropwise and the resulting mixture stirred at rt for 24h. The reaction mixture was partitioned between water (50ML) and ethyl acetate (LOOML) and the layers separated. The aqueous phase was extracted with ethyl acetate (3X30ML). The combined organics were washed with brine (50ML), dried (MGS04), filtered and concentrated in vacuo. The residue was dissolved in the minimum amount of dichloromethane and loaded onto a silica column. Purification via flash column chromatography (SI02, dichloromethane then 25% ethyl acetate/ isohexane) gave a pale yellow solid. 8H (CDCl3): 0.28 (9H, s), 1.43 (3H, t), 4.45 (2H, q), 7. 18 (1H, s), 7.83 (1H, s), 8.86 (1H, s), 9.21 (1H, br s).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 800401-70-1, Ethyl 5-bromo-1H-pyrrolo-[2,3-c]-pyridine-2-carboxylate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; OSI PHARMACEUTICALS, INC.; WO2004/104001; (2004); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem