Adding a certain compound to certain chemical reactions, such as: 65515-39-1, 2-Methoxy-4,6-dimethylnicotinonitrile, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 65515-39-1, blongs to pyridine-derivatives compound. SDS of cas: 65515-39-1
Add a I M solution of DIBAL-H in toluene (240 mL, 240 mmol) to a solution of 2-methoxy-4,6-dimethyl-pyridine-3-carbonitrile (48 g, 295.95 mmol) in DCM (480 mL)at 0 C over 2 hr. Remove the ice bath after 1 hr and stir at RT overnight. Cool in a waterbath at RT and quench by slowly adding a mixture of lMaqueous HC1 (192 mL) andAcOH (192 mL). Add DCM, separate the layers, wash the organic phase with saturated aqueous NaC1, dry over Na2504, filter and concentrate in vacuo. Subject the resulting residue to chromatography on silica, eluting with a gradient of 0-20% EtOAc/hexane to afford title compound as a solid (22.6 g, 46% yield) after solvent evaporation. ES/MS(mlz): 166 (M+H). ?H NMR (400.1 MHz, CDC13) oe 2,43 (s, 3H), 2.54 (s, 3H), 4.01 (s,3H), 6.61 (s, 1H), 10.48 (s, 1H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,65515-39-1, its application will become more common.
Reference:
Patent; ELI LILLY AND COMPANY; DOMINGUEZ, Esteban; GUO, Deqi; MADER, Mary Margaret; NGUYEN, Anh-Quan Hannah; DEL PRADO, Miriam Filadelfa; RICHETT, Michael Enrico; RODRIGUEZ, Michael John; YIP, Yvonne Yee Mai; YU, Kuo-Long; (165 pag.)WO2017/35060; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem