Synthetic Route of 131747-53-0, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 131747-53-0, name is (6-(Trifluoromethyl)pyridin-2-yl)methanol. A new synthetic method of this compound is introduced below.
Methanesulfonyl chloride (0.15 mL, 1.96 mmol) was added to a 0 C cooled solution of [6-(trifluoromethyl)pyridin-2-yl]methanol (0.32, 1.78 mmol) and Et3N (0.30 mL, 2.13 mmol) in CH2Cl2 (15 mL). The reaction mixture was stirred at room temperature for 22 h and concentrated to dryness, rendering the title compound as a white sticky solid, which was used in the next step without further purification. HPLC-MS (Method H): Ret, 9.06 min; ESI+-MS m/z: 256 (M+1).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,131747-53-0, (6-(Trifluoromethyl)pyridin-2-yl)methanol, and friends who are interested can also refer to it.
Reference:
Patent; LABORATORIOS DEL DR. ESTEVE, S.A.; GOYA, Pilar; TORRENS-JOVER, Antoni; ALMANSA-ROSALES, Carmen; DIAZ-FERNANDEZ, Jose-Luis; CAAMANO MOURE, Ana; (347 pag.)WO2017/178510; (2017); A1;,
Pyridine – Wikipedia,
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