Electric Literature of 1802-20-6, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 1802-20-6 as follows.
EXAMPLE 112 Bromine (2.3 mL, 44.6 mmol) was added dropwise to a suspension of the 6-aminonicotinic acid Compound 112a (5.08 g, 36.8 mmol) in water (20 mL) at 4 C. After the completion of the addition, the cooling bath was removed and the reaction mixture was stirred at room temperature for 4.5 h. Saturated Na2S2O5 was added slowly to the stirred mixture. The solid was collected through filtration, washed with water, and dried under vacuum overnight to give 9.30 g of 6-amino-5-bromonicotinic acid along with 3,5-dibromo-2-aminopyridine in 1:1 ration as a greenish solid; MS (ES) m/z: 217 (M+H+).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1802-20-6, its application will become more common.
Reference:
Patent; Kuo, Gee-Hong; Connolly, Peter J.; Prouty, Catherine; DeAngelis, Alan; Wang, Aihua; Jolliffe, Linda; Middleton, Steve; Emanuel, Stuart; US2003/60629; (2003); A1;,
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