As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1079179-12-6, name is 2-Chloro-3-fluoro-5-nitropyridine, molecular formula is C5H2ClFN2O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. name: 2-Chloro-3-fluoro-5-nitropyridine
To the reaction mixture of crude Compound 131 above was added 2- chloro-3-fluoro-5-nitropyridine (6 eq, 412 mg, 2.34 mmol) and CS2CO3 (6 eq, 763 mg, 2.34 mmol). The mixture was stirred at room temperature overnight and then partitioned between water and EtOAc. The organic phase was washed with aq saturated NaCl and concentrated. The residue was purified by silica gel column to give Compound 132.
With the rapid development of chemical substances, we look forward to future research findings about 1079179-12-6.
Reference:
Patent; EXELIXIS, INC.; BANNEN, Lynne Canne; BUI, Minna; JIANG, Faming; WANG, Yong; XU, Wei; (235 pag.)WO2019/148043; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem