Reference of 1256810-26-0, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1256810-26-0, name is 6-Bromo-3-methoxypicolinic acid. A new synthetic method of this compound is introduced below.
3.3 mmol of oxalyl chloride are added to a solution of 1 ml of dimethyl sulphoxide in 10 ml of dichloromethane at -60C. The mixture is stirred at -60C until the evolution of gas subsides. A solution of the solid in 10 ml of dichloromethane is added dropwise at -60C. The reaction mixture is stirred at -30C for 30 minutes, again cooled to -60C, and 8.8 mmol of triethyl- amine are added. The mixture is stirred at room temperature for 30 minutes. Water and dichloromethane are added, the phases are separated, and the aqueous phase is extracted with dichloromethane (3x). It is evaporated, mixed with toluene, dried with sodium sulphate and evaporated. The crude title compound is identified by means of the Rf.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,1256810-26-0, 6-Bromo-3-methoxypicolinic acid, and friends who are interested can also refer to it.
Reference:
Patent; SPEEDEL EXPERIMENTA AG; WO2007/31558; (2007); A1;,
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