Adding a certain compound to certain chemical reactions, such as: 850663-54-6, 4-Chloro-5-nitropyridin-2(1H)-one, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, COA of Formula: C5H3ClN2O3, blongs to pyridine-derivatives compound. COA of Formula: C5H3ClN2O3
(4c) 4-chloro-2-methoxy-5-nitropyridine 4-Chloro-5-nitropyridin-2-ol (1.18 g, 6.76 mmol) produced in Example 4 (4b) was suspended in tetrahydrofuran (15 mL) and, silver carbonate (2.80 g, 10.1 mmol) and methyl iodide (2.10 ml, 33.8 mmol) were added at room temperature, and the mixture was stirred at the same temperature for 13 hr. The insoluble material was filtered off with celite, and the filtrate was evaporated under reduced pressure. The obtained residue was purified by silica gel column chromatography (chloroform). The solvent of the object fraction was evaporated under reduced pressure to give the title object compound as a pale-yellow powder (730 mg, yield 57%). 1H-NMR (CDCl3, 400 MHz) delta: 4.03 (3H, s), 6.90 (1H, s), 8.88 (1H, s)
At the same time, in my other blogs, there are other synthetic methods of this type of compound,850663-54-6, 4-Chloro-5-nitropyridin-2(1H)-one, and friends who are interested can also refer to it.
Reference:
Patent; Kyoto Pharmaceutical Industries, Ltd.; SHIRAHASE, Hiroaki; TAKAHASHI, Kenji; SHOJI, Yoshimichi; TAKEDA, Shigemitsu; (111 pag.)US2016/207883; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem