Some scientific research about 2-Chloro-3-fluoroisonicotinic acid

The synthetic route of 628691-93-0 has been constantly updated, and we look forward to future research findings.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 628691-93-0, name is 2-Chloro-3-fluoroisonicotinic acid, the common compound, a new synthetic route is introduced below. Computed Properties of C6H3ClFNO2

Example 125: 3-(4-Bromo-2-fluoro-phenylamino)-2-chloro-isonicotinic acid; 2-Chloro-3-fluoro-isonicotinic acid (200mg, 1.14mmol) and 4-bromo-2-fluoroaniline (217mg, 1.14mmol) were added to 5ml of dry THF and the mixture was cooled to -78 0C. LiHMDS (1 M in THF, 4.0ml) was added and the mixture was allowed to warm to room temperature over night. Solid ammonium hydrochloride (1g) was added and after 1h the mixture was filtered and the volatiles were removed in vacuo. The crude material was purified by flash-chromatography using a gradient of 0-12% methanol (containig 0.5% EPO formic acid) in DCM as eluent to give 213mg (0.617mmol; 54% yield) of pure desired carboxylic acid product. LC-MS (method IiI): rt = 4.42min; m/z [M+H]+ 386/388.

The synthetic route of 628691-93-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; APPLIED RESEARCH SYSTEMS ARS HOLDING N.V.; WO2006/45514; (2006); A1;,
Pyridine – Wikipedia,
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