Adding a certain compound to certain chemical reactions, such as: 800401-70-1, Ethyl 5-bromo-1H-pyrrolo-[2,3-c]-pyridine-2-carboxylate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Formula: C10H9BrN2O2, blongs to pyridine-derivatives compound. Formula: C10H9BrN2O2
To a solution OF 5-BROMO-LH-PYRROLO [2,3-c] pyridine-2-carboxylic acid ethyl ester (Preparation 26,0. 160g, 0. 590MMOL) in DMF (anhydrous, 5ML) was added zinc (II) cyanide (0.041g, 0.35mmol) then tetrakis-triphenylphosphine palladium (0). The reaction mixture was degassed by bubbling argon through it for l Omin. The reaction mixture was heated to reflux temperature for 4. 5h then allowed to cool to rt. Water (30mL) was added and the mixture extracted with ethyl acetate (2X50ML). The combined organics were washed with brine (30mL), dried (MGS04), filtered and concentrated in vacuo. The residue was dissolved in ethyl acetate then adsorbed onto silica gel. Purification via flash column chromatography (SI02, ethyl acetate: isohexane, 1: 3, v/v) gave the title compound as a white solid. aH (CDCl3): 1.45 (3H, t), 4.49 (2H, quartet), 7.31 (1H, s), 8.09 (1H, s), 8.97 (1H, s), 9.60 (1H, br s); M/Z (ES+) = 216 [M+ H] + ; RT = 3. 03MIN.
The synthetic route of 800401-70-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; OSI PHARMACEUTICALS, INC.; WO2004/104001; (2004); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem