In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 14916-63-3, name is 6-Nitropyridin-2-amine, the common compound, a new synthetic route is introduced below. Formula: C5H5N3O2
Dichloromethane (10 ml) was added to a 50 ml reaction flask.2-Amino-6-nitropyridine (200 mg, 1.4 mmol) Starting material 1And 3-bromo-2-oxo-propionic acid ethyl ester (280 ml, 1.4 mmol),Magnetic stirring at room temperature for 1-2h,Concentrate under reduced pressure to remove the solvent,The residue is dissolved in 10 ml of ethanol (specifically anhydrous ethanol) and heated to reflux for 3 h.TLC detected the reaction was complete.After the reaction solution was naturally cooled to room temperature, it was concentrated under reduced pressure to remove the ethanol.The residue was washed with saturated sodium hydrogencarbonate solution, the aqueous layer was extracted with dichloromethane, the organic layer solution was dried over anhydrous sodium sulfate overnight, suction filtered and concentrated, and the residue was separated using silica gel column chromatography.Yellow solid, which is Intermediate 2.
The synthetic route of 14916-63-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; (9 pag.)CN107652308; (2018); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem