Reference of 184416-84-0, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.184416-84-0, name is 2,3-Dichloroisonicotinic acid, molecular formula is C6H3Cl2NO2, molecular weight is 192, as common compound, the synthetic route is as follows.
Thionyl chloride (92 mu, 1.25 mmol) is added to a mixture of 2,3-dichloro- pyridine-4-carboxylic acid (200 mg, 1.04 mmol), DCM (2 ml) and DMF (20 mu). The mixture is heated to 100C for 10 minutes in a microwave. The mixture is concentrated in vacuo. DCM (2.5 ml) and 1 ,2-dimethylhydrazine dihydrochloride (207 mg, 1.55 mmol) is added before DIPEA (1.35 ml, 7.77 mmol) in DCM (2.5 ml) is added dropwise at RT. Stirring is continued for 1 hour. The mixture is diluted with DCM and extracted with water. The combined organic layers are dried over Na2S04 and concentrated in vacuo. NMP (1 ml) and triethylamine (200 mu, 1.5 mmol) is added and the mixture heated to 190C for 25 minutes in a microwave. At RT water is added (500 mu) and the product purified by RP HPLC. Yield: 50 mg (24%). HPLC-MS: M+H=198; tR=0.44 min (METHOD l).
Statistics shows that 184416-84-0 is playing an increasingly important role. we look forward to future research findings about 2,3-Dichloroisonicotinic acid.
Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; REISER, Ulrich; WO2015/25018; (2015); A1;,
Pyridine – Wikipedia,
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