Electric Literature of 69422-72-6, Adding some certain compound to certain chemical reactions, such as: 69422-72-6, name is 2,4,6-Trichloronicotinic acid,molecular formula is C6H2Cl3NO2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 69422-72-6.
A solution of the product of EXAMPLE 1 1C (1.5 g,6.7 mmol) in dichloromethane (50 mL) was treated at room temperature with 2 drops ofN,N-dimethylformamide. Oxalyl chloride (1.27 g, 10 mmol) was added dropwise over 15 minutes and stirring was continued for 2 hours. The solution was concentrated and dried under vacuum to give the crude acid chloride. Ammonium (gas) was passed through a solution of the acid chloride in tetrahydrofuran (20 mL) and the mixture stirred at room temperature for 0.5 hours. The mixture was concentrated under vacuum and the residue purified by flash chromatography on silica gel (200-3 00 mesh) eluting with 100/1 dichloromethane/methanol to give the title compound. MS: 225 (M+H).
According to the analysis of related databases, 69422-72-6, the application of this compound in the production field has become more and more popular.
Reference:
Patent; ABBVIE INC.; Vasudevan, Anil; Penning, Thomas Dale; Chen, Huanming; Liang, Bo; Wang, Shaohui; Zhao, Zhongqiang; Chai, Dikun; Yang, Leifu; Gao, Yingxiang; Pliushchev, Marina; US2014/171429; (2014); A1;,
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