As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 800401-70-1, name is Ethyl 5-bromo-1H-pyrrolo-[2,3-c]-pyridine-2-carboxylate, molecular formula is C10H9BrN2O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Formula: C10H9BrN2O2
Sodium hydroxide solution (L. lmL, 2M, 2.23mmol) was added to a solution of 5-BROMO-LH-PYRROLO [2,3-c] pyridine-2-carboxylic acid ethyl ester (Preparation 26, 500MG, 1. 86MMOL) in ethanol (20mL), and the reaction mixture heated under reflux for 1. 5h and then concentrated in vacuo. The residue was dissolved in water (15ML) and acidified with acetic acid resulting in formation of a brown precipitate. The solid was collected by filtration and dried to give the title compound as a brown SOLID. AH (d6 DMSO): 7.08 (1H, s), 7.97 (1H, s), 8.60 (1H, s); m/z (ES+) = 241 [M+ H] +.
With the rapid development of chemical substances, we look forward to future research findings about 800401-70-1.
Reference:
Patent; OSI PHARMACEUTICALS, INC.; WO2004/104001; (2004); A2;,
Pyridine – Wikipedia,
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