The origin of a common compound about 5-(Hydroxymethyl)picolinonitrile

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 58553-48-3, 5-(Hydroxymethyl)picolinonitrile, other downstream synthetic routes, hurry up and to see.

Reference of 58553-48-3 ,Some common heterocyclic compound, 58553-48-3, molecular formula is C7H6N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

1.04 g (8.2 mmol) [OXALYLCHLORIDE] are dissolved in 8 ml dichloromethane. [AT-78C,] 1.28 g (16.4 mmol) dimethylsulfoxide are added dropwise. The solution is stirred at [- 78C] for 20 minutes, then 1 g (7.46 mmol) of the compound of Example 5A, dissolved in 7 ml dichloromethane, is added, and stirring at-78C is continued for another 2 hours. 3.4 g (33.6 mmol) triethylamine are then added dropwise, and after warming up to room temperature, the mixture is purified by column chromatography (silica, eluent cyclohexane to cyclohexane/ethyl acetate 2: 1). Yield: 0.76 g (77% ofth.) Analytical data: see above

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 58553-48-3, 5-(Hydroxymethyl)picolinonitrile, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; BAYER HEALTHCARE AG; WO2004/24700; (2004); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem