Synthetic Route of 194673-12-6, Adding some certain compound to certain chemical reactions, such as: 194673-12-6, name is Ethyl 6-oxo-2-(trifluoromethyl)-1,4,5,6-tetrahydropyridine-3-carboxylate,molecular formula is C9H10F3NO3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 194673-12-6.
A solution of ethyl 2-hydroxy-6-(trifluoromethyl)-3,4-dihydropyridine-5-carboxylate (14) (2.8 g, 11.8 mmol) and /V-bromosuccinimide (2.1 g, 11.8 mmol) in carbon tetrachloride (25 ml_) was heated at reflux overnight. The resulting precipitate was filtered off and the filtrate was concentrated under reduced pressure to afford a yellow solid that was purified by flash chromatography (silica gel 24 g, eluent gradient: from petrol: EtOAc 9:1 to 1 :1. The desired fractions were concentrated under reduced pressure and repurified by column chromatography (S1O2, 10 g, eluent petrol:EtOAC 9:1 to 1 :1). The desired fractions were concentrated under reduced pressure to afford the title compound as a white solid (890mg, 32%); 1H NMR (500 MHz, Chloroform-d) d 8.01 (d, J = 9.2 Hz, 1 H), 6.87 (d, J = 9.2 Hz, 1 H), 4.39 (q, J = 7.1 Hz, 2H), 1.39 (t, J = 7.1 Hz, 3H); LCMS (4 minute method) product at Rt = 0.44 min and ES+ m/z 236.09 [M+H]+
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 194673-12-6, Ethyl 6-oxo-2-(trifluoromethyl)-1,4,5,6-tetrahydropyridine-3-carboxylate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; THE UNIVERSITY OF SUSSEX; CARDIFF UNIVERSITY; UNIVERSITY COLLEGE CARDIFF CONSULTANTS LIMITED; WARD, Simon; BESWICK, Paul; PENNICOTT, Lewis; REUILLON, Tristan; CHUCKOWREE, Irina; VILLALONGA-BARBER, Carolina; PORTER, Roderick, Alan; (120 pag.)WO2019/166822; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem