Reference of 639091-75-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 639091-75-1, name is Methyl 2-(Boc-amino)isonicotinate. This compound has unique chemical properties. The synthetic route is as follows.
To a solution of compound 69.9 (42 g, 166.5 mmol, 1 eq) in THF (800 mL) was added LiA1H4 (12.64 g, 333 mmol, 2 eq) portion-wise at 0 C under N2. The mixture was stirred at 0 C for 1 hour, then heated to 18 C and stirred at 18 C for 14 hours. The reaction mixture was quenched by addition of 8% NaOH (15 mL), filtered and then diluted with H20(1000 mL) and extracted with EtOAc (500 mL x 3). The combined organic layers were washed with brine (1000 mL), dried over Na2SO4, filtered and concentrated under reduced pressure to give a residue. The residue was purified by column chromatography (Si02, Petroleum ether/Ethyl acetate=2: 1) to give compound 69.8 (15 g, 67 mmol, 40% yield) as a white solid. ?HNMR (400 MFIz, DMSO-d6) & 1.47 (s, 9 H), 4.50 (d, J=5.70 Hz, 2 H), 5.40 (t,J=5.92 Hz, 1 H), 6.89 – 6.99 (m, 1 H), 7.81 (s, 1 H), 8.14 (d, J=5.70 Hz, 1 H) and 9.71 (s, 1 H) ppm.
According to the analysis of related databases, 639091-75-1, the application of this compound in the production field has become more and more popular.
Reference:
Patent; CORTEXYME, INC.; LYNCH, Casey C.; KONRADI, Andrei; GALEMMO, JR., Robert A.; (218 pag.)WO2018/209132; (2018); A1;,
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