Electric Literature of 52334-51-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 52334-51-7, name is 3-Amino-5-methylpyridin-2(1H)-one, molecular formula is C6H8N2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
In a 10 mL reaction tube, a PTFE magnet is placed in a nitrogen atmosphere.Add 0.3 mmol of 2-hydroxy-3-amino-5-methylpyridine, 2.4 mmol of S8,2.1 mmol 2-bromo-3,3,3-trifluoropropene, 0.9 mmol sodium bicarbonate,0.2 mmol azobisisoheptanenitrile, 0.2 mmol of pinacol borate,4.5 mL of N,N-dimethylformamide, stirred for 15 h in a 100 C closed system,Extract three times with ethyl acetate, combine the organic phases, and wash with saturated sodium chloride solution.After drying over anhydrous magnesium sulfate, the organic solvent is removed by rotary evaporation;The obtained crude product was eluted with n-pentane and ethyl acetate.Separated by silica gel column chromatography6-Methyl-2-(2,2,2-trifluoroethyl)oxazolo[5,4-b]pyridine (yield 41%).
According to the analysis of related databases, 52334-51-7, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Fuzhou University; Weng Zhiqiang; Li Zhengyu; Dong Jingnan; (17 pag.)CN110105300; (2019); A;,
Pyridine – Wikipedia,
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