Electric Literature of 92992-85-3, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 92992-85-3, name is 2-Bromo-3,5-dimethylpyridine. This compound has unique chemical properties. The synthetic route is as follows.
To a solution of 2-bromo-3,5-dimethylpyridine D14 (0.050 g) in dry Toluene (1 ml) were added sodium terbutoxide (0.036 g, 0.376 mmol), Pd2(dba)3 (0.024 g, 0.027 mmol) , BINAP (0.050 g, 0.081 mmol) and benzophenone immine (0.054 ml, 0.322 mmol). The resulting mixture was degassed (3 x pump/N2) then heated to 80 0C. After 1.5 hours the mixture was cooled to room temperature, diluted with Et2O (100 ml) and filtered through a celite pad. The solvents were evaporated. The resulting oil was dissolved with THF (20 ml) and HCl 2 M in water (0.269 ml, 0.537 mmol) was added and stirred at room temperature for 3 hours. The solution was concentrated in vacuo and the mixture was neutralized with saturatedNaHCO3 aqueous solution and DCM was added, the two layers were separated, the aqueous layer was extracted with DCM (3 x 100 ml). The collected organic layers were filtered through a phase separator and evaporated. The red oil obtained was purified by flash chromatography on silica gel (Flash Master personal, 1O g cartridge eluting first with Cy 80%: EtOAc 20%, and then with NH32 M in MeOH). The fractions were collected, the solvent was removed in vacuo obtaining the title compound D15 (0.022 g). MS: (ES/+) m/z: 123 (M+l). C7H10N2 requires 122. 1H NMR (400 MHz, CDCl3) delta ppm: 7.77 (s, 1 H), 7.15 (s, 1 H), 4.5-4.30 (br.s, 2 H), 2.19 (s, 3 H), 2.13 (s, 3 H).
According to the analysis of related databases, 92992-85-3, the application of this compound in the production field has become more and more popular.
Reference:
Patent; GLAXO GROUP LIMITED; ALVARO, Giuseppe; AMANTINI, David; WO2010/72722; (2010); A1;,
Pyridine – Wikipedia,
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