Related Products of 59864-31-2, Adding some certain compound to certain chemical reactions, such as: 59864-31-2, name is 1-Methyl-6-oxo-1,6-dihydropyridine-2-carboxylic acid,molecular formula is C7H7NO3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 59864-31-2.
620 mg (3.7 mmol, 1 equiv.) of 1-methyl-6-oxo-1 ,6-dihydro-pyridine-2-carboxylic acid were dissolved in 5 mL of dry dichloromethane and to it DIPEA (3 equiv.) and HATU (1 equiv.) were added. After 10 min stirring at 0 ¡ãC, (4-fluorophenyl)-hydrazine hydrochloride (1.5 equiv.) was added. The reaction mixture was allowed to stir overnight at room temperature under nitrogen atmosphere. After the completion of the reaction, solvent was removed and the residue was washed with brine (two times, 5 mL) and extracted with dichloromethane (three times, 10ml_). The collected organic phase was dried over anhydrous Na2SO4, and concentrated under reduced pressure. The crude product was purified by column chromatography to obtain 200 mg of pure title compound (19percent). 1H NMR (500 MHz, CDCI3) delta: 3.4 (s, 3H), 4.39 – 4.44 (m, 2H), 6.49 – 6.50 (m, 1 H), 6.55 – 6.57 (m, 1 H), 6.82 – 6.85 (m, 2H), 7.02 – 7.06 (m, 2H), 7.48 – 7.50 (m, 1 H), 10.62 (s, 1 H); Signal of a NH proton was not observed; LC-MS: 262.2 (M+H); Purity (HPLC): 94.44 percent
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 59864-31-2, 1-Methyl-6-oxo-1,6-dihydropyridine-2-carboxylic acid, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; FERRER INTERNACIONAL, S.A.; GARGALLO VIOLA, Domingo; PALOMER BENET, Albert; (85 pag.)WO2016/16291; (2016); A1;,
Pyridine – Wikipedia,
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