Synthetic Route of 851386-40-8, Adding some certain compound to certain chemical reactions, such as: 851386-40-8, name is 4-Chloro-2,5-difluoropyridine,molecular formula is C5H2ClF2N, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 851386-40-8.
4-chloro-2,5-difluoropyridine E2 (1 .00 equivalents), 4-cyano-phenylboronic acid (1 .20 equivalents), Pd2(dba)3 (0.02 equivalent), 2-dicyclohexylphosphino-2′,6′-dimethoxybiphenyl (SPhos) (0.08 equivalents) and tribasic potassium phosphate (2.50 equivalents) are stirred under nitrogen atmosphere in a dioxane/water mixture (ratio of 10:1 ) at 1 10 C for 20 h. To the reaction mixture Celite and active carbon are added and stirred at 1 10C for 15 min. Subsequently the reaction mixture is hot filtered and the residue washed with dioxane. The reaction mixture is poured into 200 mL of a saturated sodium chloride solution and extracted with ethyl acetate. The combined organic phases are washed with saturated sodium chloride solution, dried over MgSC>4 and the solvent is evaporated under reduced pressure. The crude product obtained is purified by recrystallization in cyclohexane and the product obtained as solid. (0422) Instead of a boronic acid a corresponding boronic acid ester may be used.The synthesis of Z3 is carried out according to AAV1-1, wherein 4-chloro-2,5-difluoropyridine E2 reacts with 3-cyano-phenylboronic acid ester. eneral procedure for synthesis AAV2-1:
According to the analysis of related databases, 851386-40-8, the application of this compound in the production field has become more and more popular.
Reference:
Patent; CYNORA GMBH; ESTEBAN, Alhama Arjona; (133 pag.)WO2018/189356; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem