Electric Literature of 586-98-1, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 586-98-1 as follows.
[Methanesulfonic acid pyridin-2-y I methyl ester] (11) To a solution of 2-pyridylcarbinol (10) (300 mg, 2.70 mmol) and triethyl amine (698 mg, 6.75 mmol) in dry THF (10 ml_) at O0C was added a solution of mesylchloride (470 mg, 4.1 mmol) in dry THF (10 ml_). Reaction mixture was allowed to stir for 2 h at room temperature [reaction was followed by TLC]. Reaction mixture was concentrated to remove THF under reduced pressure and the residue was dissolved in CH2CI2 (100 ml_), washed with brine, dried over anhydrous Na2SO4 and concentrated under reduced pressure to give compound 11 (300 mg, 59%) as gum and it was taken as such for next step.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,586-98-1, its application will become more common.
Reference:
Patent; NEUROSEARCH A/S; WO2007/42545; (2007); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem