In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2546-56-7, name is 4-Chloro-3-fluoropyridine, the common compound, a new synthetic route is introduced below. HPLC of Formula: C5H3ClFN
To a solution of 4-chloro-3-fluoropyridine (10 mmol) in anhy THF and MeOH (15ml: 15ml) was added sodium methoxide (25% in MeOH, 10.5 mmol) dropwise. The mixture was refluxed overnight until the reaction completed (monitored by TLC). The mixture was poured into 100ml water and extracted with DCM (100ml x 3). The organic extract was dried over Na2SO4 and concentrated. The residue was purified by chromatography (eluent: ethyl acetate), to give a colorless liquid (55%).
The synthetic route of 2546-56-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BTG INTERNATIONAL LIMITED; WO2009/103950; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem