In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 138588-22-4, name is 3-(Pyridin-2-yl)-1,2,4-thiadiazol-5-amine, the common compound, a new synthetic route is introduced below. SDS of cas: 138588-22-4
3-Pyridin-2-yl-[l,2,4]thiadiazol-5-ylatnine (50 mg, 0.28 mmol) was placed in a vial and dissolved in dioxane (1.5 mL) and then added 3 N NaOH (1.5 mL), Then 4- methyithiophene-2-carboxiyl chloride (45 mg, 0.28 mmol) was added and the reaction heated to 50 C for 16 h. The reaction was then diluted with water and acidified with AcOH to force precipitation. The precipitates were collected by filtration. The collected solid was redissolved and concentrated onto celite (5 g). Then purified by normal phase chromatography (solvent A CH2C12, solvent B CH2Cl2/MeOH/ H40H 90: 10: 1, gradient from 0 – 60% B). Collected the desired product (72 mg, 0.24 mmol, 86%). NMR (400 MHz, DMSO-rf6) delta pm 2.25 (s, 3 H) 7.49 (ddd, J=7.55, 4.75, 1.12 Hz, 1 H) 7.65 (s, 1 H) 7.95 (id, J-7.74, 1.81 Hz, 1 H) 8.13 (d, ,/ 1.02 Hz, 1 H) 8.20 (d, J-7.91 Hz, 1 H) 8.62 – 8.74 (m, 1 H) 13.75 (br. s., i H); LCMS (M/Z): M i i 303.
The synthetic route of 138588-22-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; SCYNEXIS INC.; LIU, Hao; SLIGAR, Jessica, Marie; SPEAKE, Jason, Daniel; MOORE, Joseph, A., III; BECK, Brent, Christopher; WO2015/73797; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem