The important role of 2-Chloro-4-methylpyridine

At the same time, in my other blogs, there are other synthetic methods of this type of compound,3678-62-4, 2-Chloro-4-methylpyridine, and friends who are interested can also refer to it.

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.3678-62-4, name is 2-Chloro-4-methylpyridine, molecular formula is C6H6ClN, molecular weight is 127.57, as common compound, the synthetic route is as follows.Recommanded Product: 3678-62-4

Step 1 2-Methoxy-4-methylpyridine Procedure: A mixture of 2-chloro-4-methylpyridine (20 g, 0.156 mol) and NaOCH3 (9.3 g, 0.172 mol) in DMSO (200 mL) was stirred at 100 C. for 4 hours. The solution was added to H2O and then extracted with ethyl acetate (50 mL*2). The organic layer was washed with H2O (300 mL) brine (300 mL) and dried concentrated to give 2-methoxy-4-methylpyridine (9 g, 46%). LC-MS: 124 [M+H]+, tR=1.21 min.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,3678-62-4, 2-Chloro-4-methylpyridine, and friends who are interested can also refer to it.

Reference:
Patent; Hermann, Johannes Cornelius; Lowrie, JR., Lee Edwin; Lucas, Matthew C.; Luk, Kin-Chun Thomas; Padilla, Fernando; Wanner, Jutta; Xie, Wenwei; Zhang, Xiaohu; US2012/252777; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem