Reference of 188637-63-0, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 188637-63-0 as follows.
To a mixture of A214.2 (14.3 g, 76.5 mmol) and pyridine (14.3 mL) in anhydrous tetrahydrofuran (250 mL) was added acetic anhydride (14.3 mL), and the reaction mixture was stirred for 3 hr at room temperature. The solvent was removed under reduced pressure, and the oily residue was diluted with dichloromethane, washed with water, washed with a saturated aqueous solution of sodium bicarbonate, and dried over anhydrous sodium sulfate. Concentration followed by drying under reduced pressure afforded 16.3 g (93%) of A214.3 as an off-white solid. The compound had an HPLC retention time = 0.987 min. (Column: Chromolith SpeedROD 4.6 x 50 mm – 4 min.; Solvent A = 10% MeOH, 90% H2O, and 0.1% TFA; Solvent B = 90% MeOH, 10% H2O, and 0.1% TFA) and a LC/MS M+1 = 229.10 and 231.10.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,188637-63-0, its application will become more common.
Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; WO2006/122137; (2006); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem