Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 886365-46-4, name is 5-Chloro-3-methylpyridine-2-carboxylic acid. A new synthetic method of this compound is introduced below., Recommanded Product: 5-Chloro-3-methylpyridine-2-carboxylic acid
Example 170 Synthesis of N-(3-((4S,6S)-2-amino-4-methyl-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4,5-difluorophenyl)-5-chloro-3-methylpicolinamide The titled compound was synthesized by procedure and steps analogous to those described in Method Y, Example 163 above, but using 5-chloro-3-methyl-pyridine-2-carboxylic acid (Frontier Scientific, Inc) in step 10. MS m/z=463.0 [M+H]+. Calculated for C19H16ClF5N4O2: 462.8 1H NMR (400 MHz, CHLOROFORM-d) delta ppm 1.68 (br. s., 3H) 1.94 (t, J=12.52 Hz, 1H) 2.78 (br. s., 4H) 3.99-4.15 (m, 1H) 7.03 (br. s., 1H) 7.66 (br. s., 1H) 8.11 (br. s., 1H) 8.39 (br. s., 1H) 10.06 (br. s., 1H)
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Reference:
Patent; MINATTI, Ana Elena; LOW, Jonathan D.; ALLEN, Jennifer R.; CHEN, Jian; CHEN, Ning; CHENG, Yuan; JUDD, Ted; LIU, Qingyian; LOPEZ, Patricia; QIAN, Wenyuan; RUMFELT, Shannon; RZASA, Robert M.; TAMAYO, Nuria A.; XUE, Qiufen; YANG, Bryant; ZHONG, Wenge; US2014/249104; (2014); A1;,
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