As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 59290-81-2, name is 2-Methyl-5-nitro-3-pyridinecarboxylic acid, molecular formula is C7H6N2O4, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Recommanded Product: 2-Methyl-5-nitro-3-pyridinecarboxylic acid
A mixture of intermediate C (14 mg, 0.06 mmol), oxalyl chloride (0.3 mmol) and a catalytical amount of DMF in 1 ml DCM was stirred at r.t. for 1.5 hr. After evaporation to dryness, the resulting acid chloride was coupled with compound 17 (0.05 mmol) in 0.5 ml DCM in presence of DIEA (44 mul, 5 eq.). The reaction mixture was stirred at r.t. overnight before concentration to dryness. Preparative HPLC purification gave 28.3 mg of the product as the TFA salt. (Calculated mass: 552.6, observed mass: 552.8).
With the rapid development of chemical substances, we look forward to future research findings about 59290-81-2.
Reference:
Patent; KEMIA, INC.; WO2007/56016; (2007); A2;,
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