As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 99368-68-0, name is 6-Chloro-5-(trifluoromethyl)pyridin-3-amine, molecular formula is C6H4ClF3N2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Product Details of 99368-68-0
The crude 6-chloro-5- (trifluoromethyl) pyridin-3-amine 5(crude 1.3 g, 6.61 mmol) was dissolved in pyridine (10 ml), then 4-dimethylaminopyridine (DMAP) (50 mg) was added. di -t- butyl dicarbonate(2.17g) was added dropwise, and the mixture was stirred for 4 hours at 22 . Toluene (20ml) was added, all solvent was removed under reducedpressure. The residue was filtered through a plug of silica gel (hexane/ ethyl acetate 2: 1), to obtain t- butyl N-6- chloro-5- (trifluoromethyl)pyridin-3-yl carbamate 6.
With the rapid development of chemical substances, we look forward to future research findings about 99368-68-0.
Reference:
Patent; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; JUNG, MICHAEL E; SAWYERS, CHARLES L; OUK, SAMEDY; TRAN, CHRIS; WONGVIPAT, JOHN; (40 pag.)JP2016/11315; (2016); A;,
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