Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 4487-59-6, name is 2-Bromo-5-nitropyridine. A new synthetic method of this compound is introduced below., HPLC of Formula: C5H3BrN2O2
Example 84Synthesis of 3-[6-{4-[5-(nitro)pyridin-2-yl]piperazin-l-yl}-5-phenyl-2- (trifluoromethyl)pyrimidin-4-yl]benzenesulfonamide.Step 1;Preparation of l-(5-nitropyridin-2-yl) piperazine. 2-Bromo-5-nitropyridine (0.3g, 1.48mmol) was treated with piperazine (0.64g, 7.89mmol) in tetrahydrofuran (4mL) and the reaction mixture was stirred for 30 minutes. Subsequently the reaction mixture was poured onto ice- cold water (25mL) and extracted with ethyl acetate (25mL). The organic layer was washed with brine and evaporated to furnish the product.
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Reference:
Patent; ORCHID RESEARCH LABORATORIES LIMITED; WO2007/83182; (2007); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem