Electric Literature of 62734-08-1, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.62734-08-1, name is 2-(Chloromethyl)-4-methoxypyridine hydrochloride, molecular formula is C7H9Cl2NO, molecular weight is 194.06, as common compound, the synthetic route is as follows.
Example 11; N-cyclopropyl-3-({3-[(4-methoxypyridin-2-yl) methoxy] benzoyl} amino)-4- methylbenzamide To a stirred solution of N-cyclopropyl-3-[(3-hydroxybenzoyl) amino] -4- methylbenzamide (200 mg, 0.65 mmol) in acetonitrile (50 mL) was added anhydrous potassium carbonate (220 mg, 1.59 mmol) and 4-methoxy-2-chloromethyl-pyridine hydrochloride (150 mg, 0.75 mmol). The mixture was stirred at reflux for 16 hours, then filtered and the solvent evaporated at reduced pressure to give a gum, which was dissolved in ethyl acetate/methanol (19: 1,20 mL) and purified by chromatography on silica, eluting with ethyl acetate/methanol (9: 1) to give the compound as a white solid (250mg, 90%); NMR Spectrum : (CDC13) 0.60 (m, 2H), 0. 80 (m, 2H), 2.32 (s, 3H), 2.86 (m, 1H), 3.85 (s, 3H), 5.19 (s, 2H), 6.67 (s, 1 H), 6.75 (dd, 1H), 7.04 (d, 1H), 7.17 (dd, 1H), 7.21 (d, 1H), 7. 38 (dd, 1H), 7.48 (d, 1H), 7.54 (m, 2H), 8. 02 (s, 1H), 8. 14 (s, 1H), 8. 40 (d, 1H) ; Mass spectrum: M+H+ 432.
Statistics shows that 62734-08-1 is playing an increasingly important role. we look forward to future research findings about 2-(Chloromethyl)-4-methoxypyridine hydrochloride.
Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2005/61465; (2005); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem