New downstream synthetic route of 58539-65-4

With the rapid development of chemical substances, we look forward to future research findings about 58539-65-4.

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 58539-65-4, name is 2-Methylnicotinamide. This compound has unique chemical properties. The synthetic route is as follows. name: 2-Methylnicotinamide

To N,N-dimethylformamide dimethyl acetal (a compound represented by formula (1da)-101, 12.5 mL), 2-methyl-3-pyridine carboxamide a compound represented by formula (1d)-101, 4.69g, 34.5mmol) was added, while the methanol accumulates in an eggplant-shaped flask of distillation apparatus and stirred for 1.5 hours at 120 C. The resulting solution was then cooled, filtered, as colorless crystals 2-methyl-N-[1-(dimethylamino)methylidene]pyridine-3-carboxamide obtaining (compound represented by following formula (1c)-101) (yield 2.87 g, 92% yield).

With the rapid development of chemical substances, we look forward to future research findings about 58539-65-4.

Reference:
Patent; Sharp Corporation; Yamada, Makoto; Endo, Noritaka; Oe, Masato; (54 pag.)JP2015/117183; (2015); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem