Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 145255-19-2, name is 5-Aminopyridine-2-carboxamide. A new synthetic method of this compound is introduced below., Quality Control of 5-Aminopyridine-2-carboxamide
[1140] 60mg (0.129 mmol, 89% purity) of 2-[4-(5-chloro- 2-cyanophenyl)-5-methoxy-2-oxopyridin- 1 (2H)-yl]-3-(3- methyl-i ,2-oxazol-5-yl)propanoic acid (racemate) and 27 mg (0.194 mmol, 1.5 eq.) of 5-aminopyridine-2-carboxam- ide were initially charged in 1.0 ml of pyridine, 123 jil (0.516 mmol, 50% in ethyl acetate, 4.0 eq.) of T3P were added and the mixture was stirred at 50 C. for 2 h. The reaction mixture was cooled, 4 ml of water and 4 ml of saturated aqueous sodium hydrogencarbonate solution were added and the mixture was stirred for 10 mm. The suspension was filtered with suction and washed with water and three times with 2 ml each time of acetonitrile, and then the filtrate was lyophilized Yield: 51 mg (73% of theory).j1141] LCMS [Method 1]: R=0.83 mm; MS (ESIpos):m1z533 (M+H), j1142] ?H-NMR (400 MHz, DMSO-d5): oe [ppm]=i0.94(s, 1H), 8.84 (d, 1H), 8.22 (dd, 1 H), 8.07-8.01 (m, 2 H), 7.99 (d, 1H), 7.75-7.68 (m, 2H), 7.58-7.50 (m, 2H), 6.52 (s, 1H), 6.03 (s, 1H), 5.99 (dd, 1H), 3.88 (dd, 1H), 3.74-3.63 (m, 4H),2.14 (s, 3H)
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Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; ROeHRIG, Susanne; JIMENEZ-NUNEZ, Eloisa; SCHLEMMER, Karl-Heinz; TERSTEEGEN, Adrian; TELLER, Henrik; HILLISCH, Alexander; HEITMEIER, Stefan; SCHMIDT, Martina Victoria; ACKERSTAFF, Jens; STAMPFUss, Jan; (87 pag.)US2017/291892; (2017); A1;,
Pyridine – Wikipedia,
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