Reference of 57963-08-3 ,Some common heterocyclic compound, 57963-08-3, molecular formula is C7H10N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
To a solution of intermediate R2 (100 mg, 0.303 mmol) and 5,6-dimethylpyridin- 2-amine (43 mg, 0.333 mmol) in toluene (2.0 mL) was added trimethyl aluminium (2.0 M in toluene, 0.29 mL, 0.606 mmol) at 0 C. The reaction mixture was stirred at 100 C for 3 h. After completion of the reaction (monitored by TLC), the reaction mixture was quenched with water, extracted EtOAc (50 mL), dried over anhydrous Na2S04 and the solvent was evaporated under reduced pressure. The crude product was purified by column chromatography to afford intermediate S52 (60 mg, 47%) as a pale yellow solid. 1H NMR (DMSO-d6, 400 MHz) delta: 11.12 (1H, s), 8.35 (1H, s), 8.29 (1H, s), 7.91- 7.89 (1H, d, J = 8.0Hz), 7.59-7.57 (1H, d, J = 7.6Hz), 3.82 (3H, s), 2.38 (3H, s), 2.23 (3H, s).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,57963-08-3, its application will become more common.
Reference:
Patent; H. LUNDBECK A/S; MALTAS, Philip James; WATSON, Stephen; LANGGARD, Morten; DAVID, Laurent; WO2014/114779; (2014); A1;,
Pyridine – Wikipedia,
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