Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 16098-21-8, name is 3-Bromo-1-methyl-5-nitropyridin-2(1H)-one. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 3-Bromo-1-methyl-5-nitropyridin-2(1H)-one
To a stirred solution of 3-bromo-l-methyl-5-nitropyridin-2(lH)-one (2.1 g, 9.012 mmol, 1.0 eq) and potassium (5-chloro-2-fluorophenyl)trifluoroborate (3.2 g, 13.518 mmol, 1.5 eq) in dioxane (50 mL) was added a 2M solution of Na2C03 (1.91 g, 18.024 mmol, 2.0 eq) in H20 at RT. The resulting mixture was purged with nitrogen for 10 min followed by addition of Pd(dppf)Cl2.DCM (0.368 g, 0.450 mmol, 0.05 eq), again purged with nitrogen for 10 min. The reaction mixture was heated at l00C for overnight. The progress of reaction was monitored by LCMS. The reaction mixture was diluted with water (50 mL), extracted with EtOAc (2 x 100 mL). The combined organic layers were washed with water (50 mL), with brine (50 mL), dried over Na2S04, concentrated and purified by combi flash chromatography [silica gel 100-200 mesh: elution 0-30 % EtOAc in Hexane] to afford the desired compound 3-(5-chloro-2-fluorophenyl)-l-methyl-5-nitropyridin-2(lH)-one (1.6 g, 62.99%) as off white solid. LCMS: (M+l)+: 283.2.
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Reference:
Patent; INTEGRAL BIOSCIENCES PVT. LTD.; PUJALA, Brahmam; PENDHARKAR, Dhananjay; AGARWAL, Anil Kumar; KUMAR, Varun; ARYA, Satish Kumar; CHAKRAVARTY, Sarvajit; (0 pag.)WO2020/12357; (2020); A1;,
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