Synthetic Route of 204378-41-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 204378-41-6, name is Methyl 6-chloro-4-methoxypicolinate. This compound has unique chemical properties. The synthetic route is as follows.
To a solution of methyl 6-chloro-4-methoxypicolinate 25 (500 mg, 2.48 mmol) and pentan-3-ylzinc(II) bromide (10 mL of a 0.5 M solution in THF) in dioxane (10 mL) Pd(dppf)Cl2 (21 mg, 25 mol) was added under argon. The mixture was stirred at 75°C for 18 h. The mixture was cooled the rt and the reaction was quenched by carefully adding water (10 mL). The mixture was filtered and the filtrate was extracted twice with EA (2×100 mL). The combined organic extracts were dried over MgSO4, filtered and concentrated. During the reaction the methyl picolinate was transformed to the pent-3-yl picolinate, and formation of the 6-(pent-2-yl)picolinate isomer complicated the purification and compromised the yield. Hence, the crude product was purified by CC on silica gel eluting with heptane:EA 9:1 to give pentan-3-yl 4-methoxy-6-(pentan-3-yl)picolinate 26 (145 mg, 20percent) as a pale yellow oil
According to the analysis of related databases, 204378-41-6, the application of this compound in the production field has become more and more popular.
Reference:
Article; Bolli, Martin H.; Lescop, Cyrille; Birker, Magdalena; De Kanter, Ruben; Hess, Patrick; Kohl, Christopher; Nayler, Oliver; Rey, Markus; Sieber, Patrick; Velker, Joerg; Weller, Thomas; Steiner, Beat; European Journal of Medicinal Chemistry; vol. 115; (2016); p. 326 – 341;,
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