Adding a certain compound to certain chemical reactions, such as: 131747-62-1, 3-(Trifluoromethyl)pyridine-2-carboxaldehyde, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Computed Properties of C7H4F3NO, blongs to pyridine-derivatives compound. Computed Properties of C7H4F3NO
General procedure: To a soln. of amine B-1 (1 eq) and aldehyde BB-12 (1.2 eq) in THF (4 to 5 mL/mmol) was added AcOH (1.5 eq) and the rxn mixture was stirred for 5 min at RT. NaBH(OAc)3 (1.5 to 2 eq) was added portionwise and the rxn mixture was stirred at RT for a given time (see Table 40). When necessary to reach completion of the rxn an extra amount of NaBH(OAc)3 (0.2 to 1 eq) was added. The rxn mixture was quenched with a sat. aq. soln. of NaHC03 and extracted with DCM. The combined org. phases were washed with brine, dried over MgS04 and concentrated in vacuo. When necessary, the crude was purified by CC using Hept/EtOAc/MeOH.
The synthetic route of 131747-62-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; IDORSIA PHARMACEUTICALS LTD; FROIDEVAUX, Sylvie; HUBLER, Francis; MURPHY, Mark; RENNEBERG, Dorte; STAMM, Simon; (266 pag.)WO2019/137927; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem