Synthetic Route of 13362-30-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 13362-30-6, name is Ethyl 2-aminoisonicotinate. This compound has unique chemical properties. The synthetic route is as follows.
[1- [5-CHLORO-2- (4-METHOXY-BENZYLOXY)-PHENYL]-PENTANE-1,] 4-dione (1.04g, 2. [9MMOL)] and 2- amino-isonicotinic acid ethyl ester (0.54g, 3. [2MMOL)] (Linschoten et [AL,] W00066557) were heated in toluene (0. 5ml) in a sealed vessel at [150C] for 12 hours. Upon cooling, the residue was purified by chromatography on silica gel with isohexane/EtOAc (15%) as eluant, to give the title compound (510mg, 36%). [1H] NMR [(400MHZ,] CDCl3) 1.31 (3H, t, J=7.5Hz), 2.29 (3H, s), 3.79 (3H, s), 4.29 (2H, q, J=7.5Hz), 4.59 (2H, s), 6.12 (1H, d, J=3.5Hz), 6.32 (1H, d, J=3.5Hz), 6.58 (1H, broad d, J=9Hz), 6.79 (2H, d, J=8.5Hz), 6.98 (2H, d, J=8.5Hz), 7.05 (1 H, dd, J=3,9Hz), 7.26 (1 H, d, under CDCI3), 7.40 (1 H, broad s), 7.66 (1 H, dd, J=1.5, 7Hz), 8.52 (1 H, d, J=7Hz). LC/MS t=4.01 min [MH+] 477/479
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 13362-30-6, Ethyl 2-aminoisonicotinate.
Reference:
Patent; GLAXO GROUP LIMITED; WO2003/101959; (2003); A1;,
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