Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 22280-60-0, name is 6-Chloro-2-methyl-3-nitropyridine. A new synthetic method of this compound is introduced below., Safety of 6-Chloro-2-methyl-3-nitropyridine
6-methoxy-3-nitro-2-picoline 0.46 gm (20 mMol) sodium were dissolved in 15 mL anhydrous methanol. To this solution were added 2.3 gm 6-chloro-3-nitro-2-picoline in portions. The resulting mixture was stirred for 18 hours at room temperature and then 1 hour at reflux. The reaction mixture was poured into 100 mL of ice water with vigorous stirring. The suspension was filtered and the solid dried at 30 C. under reduced pressure for 18 hours to provide 2.04 gm (91%) of the desired compound as a tan solid.
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Reference:
Patent; Eli Lilly and Company; US5874427; (1999); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem